Showing posts with label RESEARCH PAPER. Show all posts
Showing posts with label RESEARCH PAPER. Show all posts
Sunday, August 30, 2026
Professor Jon Stone - Functional Neurological Disorder (FND) and MS - looking for a treatable cause of disability
RECOGNISING FUNCTIONAL SEIZURES - PROF JON STONE
WORLD RESPECTED NEUROLOGIST, PROFESSOR JON STONE
ON
RECOGNISING FUNCTIONAL SEIZURES
The use of amantadine in catatonia
We read with interest the excellent
Personal View by Olivier Rascol and
colleagues on the use of amantadine
in Parkinson’s disease and other
movement disorders.1
One movement
disorder for which amantadine
has shown some benefit but the
authors did not mention is catatonia.
Catatonia is a neuropsychiatric
syndrome that occurs in association
with psychiatric disorders such as
schizophrenia and bipolar disorder,
and also various neurological diseases,
including autoimmune encephalitis.
Characteristic clinical signs include
stupor, mutism, posturing, catalepsy,
echophenomena, mannerisms,
stereotypies, and negativism.
Catatonia has been associated
with substantial morbidity and
complications, including pneumonia,
acute kidney injury, and pulmonary
embolus.
https://drive.google.com/file/d/1EVEua8i4HrJighmDezUBaBIs3NOnw9aq/view?usp=sharing
FND Functional Neurological Disorder in Aotearoa/NZ 3.4.24
THIS IS A POWER POINT USED IN CONFERENCE WITH NEUROLOGIST M PHILLIPS AND THE HEAD OF MEDICINE IN 2023
https://drive.google.com/file/d/1ZgLKSDnjE9Ss85-rT5xQWTbRr2CJEoMM/view?usp=sharing
Correction to Lancet Neurol 2022; 21: 125–39
In this Article, in the Summary, the
number of countries in which the
trials were done should be 18. In the
Outcomes section of Methods, the
prespecified efficacy endpoints “change
from baseline in subjective WASO and
latency to sleep onset (LSO) at months
1 and 3” should be deleted as they are
not reported. In the Statistical analysis
section of Methods, .....
https://drive.google.com/file/d/1kXO8xIHI4aw_dOGwVKKTV57eOYLQ4UtC/view?usp=drive_link
Friday, August 28, 2026
Brain imaging research is thriving in functional neurological disorder
1. Introduction
Functional neurological disorder (FND) is a condition at the neurology-psychiatry interface that impacts individuals across the lifespan (Hallett et al., 2022). The conceptualization of FND in the 20th century was fraught with dualistic perspectives of brain versus mind – exemplified by outdated terms such as “hysteria” and “psychogenic”. Structure and function are closely coupled in the human brain, and neuroimaging research in FND provides an opportunity to bridge the science of brain and mind in this prevalent and potentially disabling condition (Finkelstein et al., 2025, O’Mahony et al., 2023). Advancing the neuroscience of FND further erodes artificial distinctions between brain health and mental health – and offers the potential to develop novel mechanistically-informed treatments.
https://www.sciencedirect.com/science/article/pii/S221315822600063X
Functional Neurologic Disorder (NIH)
What is functional neurologic disorder?
Functional neurologic disorder (FND) refers to a neurological condition caused by changes in how brain networks work, rather than changes in the structure of the brain itself, as seen in many other neurological disorders. Physical symptoms of FND are genuine but cannot be explained by changes in the brain structure. The exact cause of FND is unknown.
https://www.ninds.nih.gov/health-information/disorders/functional-neurologic-disorder
Functional neurological disorder: Practical management (SCIENCE DIRECT)
Functional Neurological Disorder (FND) is a common and disabling condition seen by nearly every clinician in nearly every clinical setting. There are multiple subtypes with seizure and motor/movement being the most common. There is high health care utilization and costs, and many patients have a chronic course and remain disabled. It is clear from research over the past two decades that abnormalities in brain network activity are implicated in the pathophysiology of FND. Diagnosis requires positive criteria and knowing how to obtain a good history and avoid common pitfalls. There are evidence-based treatments and expert consensus recommendations. A multidisciplinary team knowledgeable about the disorder is important for the best outcomes but there is much more work to be done. This review will focus on the practical aspects of diagnosing and managing FND.
https://www.sciencedirect.com/science/article/pii/S187874792500090X
RESEARCH FND (FND SOCIETY)
This page highlights current research projects in the area of functional neurological disorder (FND). If you would like to learn more about any of the studies, please follow the links below. If you are a researcher and want your project added to the website, please complete the Research Project Submission Form.
Advances in functional Neurological disorder
Functional neurological disorder (FND) is a fascinating and important area of neurological practice. It has a rich history and interfaces with philosophy, psychiatry and psychology. It is a very common condition, and one that produces very high levels of disability, impaired quality of life and health and social care costs. The disorder is still beset with myths and misunderstandings, yet the field is rapidly expanding, with real progress being made in understanding its pathophysiology, heterogeneity and effective treatment. We commissioned this topic collection ‘Advances in functional neurological disorder’ to reflect the rapid development of this important area of medicine.
Thursday, August 27, 2026
Genetic and Early-Life Vulnerability in Functional Neurological Disorder: A Large-Scale Retrospective Cohort Study
Functional neurological disorder (FND) is a common and disabling condition with diverse presentations, such as motor (weakness, tremor, dystonia, gait), sensory, cognitive, and seizure-like symptoms, often in combination.1 It is understood as a disorder of brain network dysfunction, in which the brain generates overly strong predictions about body states that override incoming sensory and motor signals, and symptoms arise from this mismatch.2 Historically, FND has been conceptualised in terms of psychological stress or traumatic experiences, often arising in childhood.3 However, contemporary models situate it within a broader biopsychosocial framework, in which early-life biological influences are poorly characterised compared to psychosocial factors. Previously reported inherited and......
Bioxytran Reports Encouraging Clinical Observations in First Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Patient Treated with PLICID, a Novel Galectin Antagonist Designed with Artificial
Once-weekly intravenous treatment was associated with reported improvements in finger function and walking ability, with no adverse events reported during treatment
Why Do Doctors Sometimes Laugh When Watching Seizures? Scientists Investigated This Surprisingly Awkward Medical Reaction
Two epileptologists spent five years giving the same lecture on functional seizures on three continents. Each time, they showed the same patient videos. Each time, an unannounced observer in the room counted how many people laughed.
At grand rounds in the United States, roughly 57% of the medical audience did. At an epilepsy symposium in Marburg, Germany, about 5%. At an epilepsy course in São Paulo, about 8%. At the Turkish Epilepsy Congress in Bodrum, about 13%, and about 17% across the remaining countries.
https://www.medicaldaily.com/doctors-laughter-functional-seizures-survey-477170
Levodopa exacerbated tremor in Parkinson's disease
Background:
Levodopa is considered the most effective pharmacological therapy for Parkinson's disease (PD). However, it can cause side effects including diverse types of dyskinesia. In rare cases, tremor worsening has been reported in patients with PD taking levodopa. The frequency of this effect in clinical practice is unclear, and the phenomenology is poorly characterized.
Objectives:
We aimed to assess the frequency, clinical features, and factors associated with tremor exacerbated by levodopa in patients with PD.
Methods:
We studied a cohort of 274 consecutive patients with PD and determined the frequency of tremor exacerbated by levodopa.
Results:
Tremor exacerbation with levodopa was identified in four patients (1.46%) and 1.55% of patients taking levodopa. There were two men and two women, with ages ranging from 53 to 73 years at the time of evaluation. All patients experienced a consistent worsening of rest tremor within 20 min of taking a low dose of levodopa (62.5 mg or 125 mg). No benefit from biperiden or amantadine was observed for levodopa-exacerbated tremor in any of the cases. None of the patients showed signs of atypical parkinsonism or abnormal MRI. Patients with levodopa-exacerbated tremor were very reluctant to take more than a small dose of levodopa or any dose at all, hampering potential benefits for other parkinsonian features such as rigidity, bradykinesia, and parkinsonian gait.
Conclusion:
Tremor exacerbated by levodopa is an uncommon side effect in patients with PD that limits the benefit of this therapy.
Unresponsive in the PACU: A Case Report of Functional Neurological Symptom Disorder and Review of Recent Literature
- James P. Chung
- Arnav Sugavanam1
- Joseph G. Tharion,
Journal of Obstetric Anaesthesia and Critical Care 16(2):p 172-178, Jul-Dec 2026. | DOI: 10.4103/JOACC.JOACC_68_26
Functional neurological symptom disorder (FND), also known as conversion disorder, is a somatoform disease that can cause neurological deficits without anatomical or physiological causes. It can be caused by any physical or psychological stressor, including trauma, hospital admission, surgery, as well as having to undergo anesthesia. We report about a pediatric patient (with a history of previous FND) who became suddenly unresponsive and exhibited seizure-like activity in the postanesthesia care unit after undergoing general anesthesia for a gynecological procedure (intrauterine device placement). After undergoing largely normal testing, including electrolytes, imaging, and consultation from pediatric neurology, she spontaneously recovered and was eventually discharged to psychiatry follow-up. FND is a debilitating disease both physically and mentally for both patients and families; diagnosis and treatment both need multidisciplinary involvement. Ultimately, individually tailored perioperative care is needed for patients with a history of FND; the anesthesiologist’s role in preparing patients and their families for surgery and anesthesia, as well as appropriate follow-up care, may improve long-term patient outcomes.
When Cryptogenic Is Not Cryptogenic: Carotid Web as a Cause of Recurrent Embolic Stroke
A carotid web is an under-recognized vascular abnormality increasingly identified as a cause of embolic ischemic stroke in younger patients without conventional vascular risk factors. Delayed diagnosis may lead to recurrent cerebrovascular events despite otherwise unrevealing investigations......
https://www.cureus.com/articles/491998-when-cryptogenic-is-not-cryptogenic-carotid-web-as-a-cause-of-recurrent-embolic-stroke#!/
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